The availability of hGH and insulin has increased dramatically since the development of recombinant technology. Before the invention of this technology, which produces human hormones from bacteria by introducing copies of DNA strands into the bacteria and boosting production, insulin was frequently derived from cows or pigs, and human growth hormone (hGH) had to be obtained from cadavers (dead people) on a regular basis (a part of the brain). Scientists created hGH as the first recombinant hormone after realizing that dwarf children, the population getting cadaveric hGH to treat growth retardation brought on by GH deficiency, were being diagnosed with an unique brain condition.
In order to deploy the resources required to meet the demand that recombinant insulin would create, this allowed for a tiny test market. Early adopters used doses based on procedures created for dwarf children, unlike the experience with AAS, and dived into hGH like pigs digging for truffles. Not simply the muscles grew tremendously as a result. The men’s abdomens swelled enlarged like some kind of Willy Wonka-esque special effect, and the bones in their hands, feet, and faces all grew out of proportion. It’s possible that using insulin and hGH together made the abdomen symptoms worse. Many people now use hGH at a lower dose and match their insulin with meals and exercise, while usage habits vary.
What Is the Appropriate Dose?
The question of “What is the right dose” then arises. There is certainly more than one correct response to this question. It is first assumed that a person does not have a medical condition that would raise the possibility of a negative (unfavorable) side effect, which could be lethal in some circumstances.
Although testosterone replacement therapy (TRT) or AAS abuse was originally dogmatically believed to be the cause of or a worsening of heart disease and prostate cancer, it now appears that this is not the case in doses that are within or close to the upper physiologic limit. The main cause for concern should be a history of blood clots (thrombophilic illness), which can be either spontaneous or familial (blood clots in the family).
The possibility of developing a personality disorder or psychosis is very important, particularly in teenagers and young adults. This may result from both the sharp decline in androgen levels after going off-cycle and the noticeably increased amounts of androgens present during cycles. It has been speculated that one well-known example involving a high school student who committed himself after being abruptly removed from AAS (on a doctor’s recommendation) may have been a factor. Given that the boy was also receiving psychiatric treatment and taking medicine for a mental health illness, it is questionable how reliable this assertion is.
Research suggests that, in predisposed individuals, supraphysiologic testosterone can enhance the size of response to prompted aggressiveness but does not increase spontaneous aggression, despite the denial of the existence of “roid fury.” 8 This implies that an AAS user who is prone to losing his temper will react more forcefully and/or angrily if you annoy him. The individual shouldn’t, however, lose their temper without cause. When choosing to experiment with AAS, one should be aware of additional potential risks (both legal and health-related).
